Benjamin P C Chen Selected Research

DNA-Activated Protein Kinase

1/2021	DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly.
11/2014	The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.
12/2012	New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress.
6/2012	Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment.
4/2011	Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
1/2009	DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.

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Benjamin P C Chen Research Topics

Disease

12	Neoplasms (Cancer) 01/2021 - 06/2011
9	Ataxia Telangiectasia (Louis Bar Syndrome) 10/2021 - 05/2006
6	Carcinogenesis 10/2016 - 02/2004
4	Lung Neoplasms (Lung Cancer) 01/2020 - 02/2015
4	Genomic Instability 05/2014 - 06/2010
3	Premature Aging 02/2022 - 01/2020
3	Progeria (Hutchinson Gilford Syndrome) 02/2022 - 01/2020
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 02/2015
3	Chromosomal Instability (Chromosome Stability) 10/2016 - 01/2011
2	Radiation Injuries (Radiation Sickness) 01/2020 - 12/2019
2	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 01/2017
2	Chromosome Aberrations (Chromosome Abnormalities) 01/2014 - 03/2013
2	Glioblastoma (Glioblastoma Multiforme) 03/2012 - 10/2011
1	Hemolytic Anemia 01/2021
1	Laminopathies 01/2020
1	Hyperglycemia 01/2018
1	Neoplasm Metastasis (Metastasis) 10/2016
1	Hypersensitivity (Allergy) 12/2014
1	Carcinoma (Carcinomatosis) 10/2011
1	Graft vs Host Disease (Graft-Versus-Host Disease) 08/2011
1	Bone Marrow Failure Disorders 04/2011
1	Fanconi Anemia (Fanconi's Anemia) 04/2011
1	Vascular Remodeling 01/2003

Drug/Important Bio-Agent (IBA)

21	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 02/2004
14	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2021 - 10/2006
10	Phosphotransferases (Kinase)IBA 10/2021 - 05/2006
6	DNA-Activated Protein KinaseIBA 01/2021 - 01/2009
4	Pharmaceutical PreparationsIBA 12/2019 - 01/2014
2	Lysophosphatidic Acid ReceptorsIBA 02/2022 - 01/2020
2	4-hydroxy-3,5-dimethoxybenzaldehydeIBA 01/2020 - 12/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2019 - 05/2013
2	pyrimidineIBA 05/2019 - 01/2017
2	Small Interfering RNA (siRNA)IBA 12/2014 - 03/2012
2	CamptothecinIBA 12/2014 - 03/2013
2	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 11/2014 - 09/2006
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2021
1	phenylhydrazine (phenylhydrazine hydrochloride)IBA 01/2021
1	DEAE-Dextran (Pulsar)IBA 01/2021
1	Adenosine Triphosphatases (ATPase)IBA 01/2020
1	prelamin AIBA 01/2020
1	ATPases Associated with Diverse Cellular ActivitiesIBA 01/2020
1	Drug CombinationsIBA 12/2019
1	vanillinIBA 12/2019
1	EnzymesIBA 01/2018
1	lysophosphatidic acidIBA 01/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2018
1	lens epithelium-derived growth factorIBA 01/2018
1	Vascular Endothelial Growth Factor CIBA 01/2018
1	Androgen Receptors (Androgen Receptor)IBA 01/2017
1	Biological ProductsIBA 01/2017
1	Polynucleotide 5'-Hydroxyl-Kinase (Kinase, Polynucleotide)IBA 01/2017
1	AndrogensIBA 01/2017
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 10/2016
1	8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- oneIBA 02/2015
1	ZinostatinIBA 12/2014
1	Hydroxyurea (Hydrea)FDA LinkGeneric 12/2014
1	ParaquatIBA 12/2014
1	SeleniumIBA 05/2013
1	Cisplatin (Platino)FDA LinkGeneric 03/2013
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 03/2013
1	Lamin Type A (Lamin A)IBA 03/2013
1	Casein Kinase II (Casein Kinase 2)IBA 03/2012
1	Alanine (L-Alanine)FDA Link 04/2011
1	DNA HelicasesIBA 06/2010
1	Protein Kinases (Protein Kinase)IBA 01/2009
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2009
1	ChromatinIBA 12/2005
1	Proteins (Proteins, Gene)FDA Link 01/2003

Therapy/Procedure

8	Therapeutics 01/2021 - 01/2014
2	Radiotherapy 01/2021 - 01/2017
1	Immunotherapy 01/2021
1	Drug Therapy (Chemotherapy) 02/2015
1	Homologous Transplantation 08/2011